The Search for the Legacy of the USPHS Syphilis Study at Tuskegee is a collection of essays from experts in a variety of fields seeking to redefine the legacy of the infamous Tuskegee Syphilis Study. The essayists place the legacy of the study within the evolution of racial and ethnic relations in the United States. Contributors include two leading historians on the study, two former United States Surgeons General, and other prominent scholars from a wide range of fields.

We introduce a new and time-efficient memory-encoding paradigm for functional magnetic resonance imaging. This paradigm is optimized for mapping multiple contrasts using a mixed design, using auditory and visual stimuli. We demonstrate that the paradigm evokes robust neuronal activity in typical sensory and memory networks. We were able to detect auditory and visual sensory-specific encoding activities in auditory and visual cortices. Also, we detected stimulus-selective activation in environmental-, voice-, scene-, and face-selective brain regions. A subsequent recognition task allowed the detection (...) of sensory-specific encoding success activity in both auditory and visual cortices, as well as sensory-unspecific positive ESA in the hippocampus. Further, sensory-unspecific negative ESA was observed in the precuneus. Among others, the parallel mixed design enabled sustained and transient activity comparison in contrast to rest blocks. Sustained and transient activations showed great overlap in most sensory brain regions, whereas several regions, typically associated with the default-mode network, showed transient rather than sustained deactivation. We also show that the use of a parallel mixed model had relatively little influence on positive or negative ESA. Together, these results demonstrate a feasible, versatile, and brief memory-encoding task, which includes multiple sensory stimuli to guarantee a comprehensive measurement. This task is especially suitable for large-scale clinical or population studies, which aim to test task-evoked sensory-specific and sensory-unspecific memory-encoding performance as well as broad sensory activity across the life span within a very limited time frame. (shrink)

Xenotransplantation is defined as “any procedure that involves the transplantation, implantation, or infusion into a human recipient of either live cells, tissues, or organs from a nonhuman animal source, or human body fluids, cells, tissues or organs that have had ex vivo contact with live nonhuman animal cells, tissues, or organs.” Xenotransplantation has been viewed by desperate patients and their surgeons as a solution to the problem of the paucity of human organs available for transplantation. Foes of xenotransplantation argue that (...) the use of animal organs degrades the human race and should be avoided.In this paper, we briefly review the cultural context of xenotransplantation and explore the infectious disease risk of xenotransplantation. The United States Code of Federal Regulations requires life-long surveillance of a xenotransplantation recipient due to the largely unknown risk of novel infectious disease transmitted across species, known as xenogeneic infectious disease. We argue that despite being in the interest of protecting the public health, the imposition of lifelong surveillance requirements on xenotransplant recipients effectively abrogates the right to withdraw from a clinical trial after the transplantation has taken place. Moreover, we argue that a waiver of the right to withdraw should be made explicit in the interest of full disclosure, out of respect for the research subject’s right of self-determination. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Hildegard and HolismSuzanne M. Phillips (bio) and Monique D. Boivin (bio)Keywordsbiopsychosocial, integration, medieval, mental illnessWe appreciate the careful and enriching commentary offered by Kroll and by Radden on our paper about holistic views of mental illness in the writings of the twelfth-century abbess and healer Hildegard of Bingen. Both reviewers are well-established figures in the study of historical perspectives on mental illness, an area that we have just (...) begun to explore. We are glad for the opportunity to respond to their observations and thereby to continue the dialogue.First, we would like to clarify our purpose in preparing this paper. Nowhere do we claim that Hildegard used a biopsychosocial model of mental illness, either in addressing the needs of the particular case of Sigewiza, or more generally in her writings on illness and health. In fact, we agree with Kroll (2007, 370), when he states that Hildegard did not use a biopsychosocial model. We use the term “biopsychosocial” only three times in the paper, always by contrast with what we see in Hildegard’s writings. The present-day biopsychosocial model focuses on getting a range of perspectives on the table, encouraging the consideration of biological, psychological, and social issues when thinking about mental illness. This is a good thing, but we argue that it does not go far enough. Specifically, there has been insufficient attention to ways these perspectives might interact.How, then, might we describe Hildegard’s way of conceptualizing mental illness? In place of the label “biopsychosocial model,” Kroll suggests that Hildegard’s approach could be described as a “religious model” (p. 372). Here we disagree. By our reading, Hildegard’s description of mental illness involves religious components, certainly, but also humoral, astrological, interpersonal, community, and intrapsychic components. Radden correctly notes that we are not so much interested in the particular components as we are in their interactions. We are attracted to Hildegard’s writings because she attends to these interactions. Our students, like Kroll’s (p. 371), are curious about mind–body relationships, which represent one example of the interplay between components. Our concern is that the current biopsychosocial model often fails to satisfy our own, and our students’, interest in the nature of those interactions. Our hope is that Hildegard’s writings might help us to think more richly about the interactions.As Radden (2007, 373) points out, present-day psychiatrists and psychologists do in fact use mul-ticausal accounts of depression. And we agree that such accounts need not be reductionistic (Kroll, 371). But we also recognize that psychology and psychiatry have well-established reductionist (more specifically, materialist) habits. To borrow [End Page 377] Kroll’s phrase, the biological model threatens “to swallow all other models” (p. 371). We must guard against such reductionism, given the habits of our disciplines. As we noted, McHugh and Slavney (1998) respond to that threat by building walls between the perspectives, suggesting that we might use different perspectives when thinking about different sorts of problems. We think that there ought to be more synthetic, holistic ways of responding to that threat, and we are hopeful that Hildegard’s writings can help us to develop those.At a basic level, we see Hildegard asking different questions than people ask today. On the first page of his commentary, for example, Kroll poses the question of “which of these three modalities [bio-, psycho-, social] may be sufficient” (p. 369) in the particular medieval text. We found that the sufficiency of one modality or another does not concern Hildegard. We are not able to speak to the general point that Kroll raises, that one or another element is emphasized depending on the goal of the medieval text; we can report our experience in reading Hildegard, where we found no sense in which one or another component is privileged. Even though Hildegard operated within a thoroughly religious context, we did not find examples of her subsuming other factors under religion. Everything interacts with spiritual concerns, to be sure, but everything also interacts with the biological, and with the interpersonal, and with the astrological. Although it may seem odd to us post-Darwinian thinkers, Hildegard’s model is essentially... (shrink)

Current efforts to think holistically about mental disorder may be assisted by considering the integrative strategies used by Hildegard of Bingen, a twelfth-century abbess and healer. We search for integrative strategies in the detailed records of Hilde-gard’s treatment of the noblewoman Sigewiza and in Hildegard’s more general writings. Three strategies support Hildegard’s holistic thinking: the use of narrative approaches to mental illness, acknowledging interdependence between perspectives, and applying principles of balance to the relationships between perspectives. Applying these three strategies to (...) the present-day conceptualization and treatment of mental disorder could move us toward a more thoroughly integrated understanding of the field. (shrink)

We discuss how a novel can illuminate the moral dimensions of science and healthcare. The critical distance afforded by the novel pro.

John Searle roundly rejects what he calls the Bad Argument: a long-standing equivocation in philosophy over the contents and the objects of perception. But, as Josh Armstrong points out, this insight is not unique to Searle. By the late 19th Century the equivocation had been observed by Franz Brentano and students of his, such as Alexius Meinong and Kazimierz Twardowski, and was highlighted too in the 20th century by G. E. M. Anscombe. What Armstrong does take to be a novel (...) to Searle is his use of this observation to undermine some of the primary objections to a realist theory of perception. In fact, though, it had already been put to much the same use by Mary Shepherd in her 1827 book Essays on the Perception of an External Universe and Other Subjects Connected with the Doctrine of Causation. Shepherd not only argues that the equivocal use of the term “things we perceive” is a crucial flaw in Berkeley’s case for Idealism, but also goes on to use this in service of her own, largely realist, theory of perception. (shrink)

One in three university students experiences mental health problems during their study. A similar percentage leaves higher education without obtaining the degree for which they enrolled. Research suggests that both mental health problems and academic underperformance could be caused by students lacking control and purpose while they are adjusting to tertiary education. Currently, universities are not designed to cater to all the personal needs and mental health problems of large numbers of students at the start of their studies. Within the (...) literature aimed at preventing mental health problems among students (e.g., anxiety or depression), digital forms of therapy recently have been suggested as potentially scalable solutions to address these problems. Integrative psychological artificial intelligence (AI) in the form of a chatbot, for example, shows great potential as an evidence-based solution. At the same time, within the literature aimed at improving academic success, the online life-crafting intervention in which students write about values and passions, goals, and goal-attainment plans has shown to improve the academic performance and retention rates of students. Because the life-crafting intervention is delivered through the curriculum and doesn’t bear the stigma that is associated with therapy, it can reach larger populations of students. But life-crafting lacks the means for follow-up or the interactiveness that online AI-guided therapy can offer. In this paper, we propose to integrate the current literature on chatbot interventions aimed at the mental health of students with research about a life-crafting intervention that uses an inclusive curriculum-wide approach. When a chatbot asks students to prioritize both academic as well as social and health-related goals and provides personalized follow-up coaching, this can prevent -often interrelated- academic and mental health problems. Right on-time delivery, and personalized follow-up questions enhance the effects of both -originally separated- intervention types. Research on this new combination of interventions should use design principles that increase user-friendliness and monitor the technology acceptance of its participants. (shrink)

PurposeAlthough an increasing body of literature suggests a relationship between brain irradiation and deterioration of neurocognitive function, it remains as the standard therapeutic and prophylactic modality in patients with brain tumors. This review was aimed to abstract and evaluate the prediction models for radiation-induced neurocognitive decline in patients with primary or secondary brain tumors.MethodsMEDLINE was searched on October 31, 2021 for publications containing relevant truncation and MeSH terms related to “radiotherapy,” “brain,” “prediction model,” and “neurocognitive impairments.” Risk of bias was (...) assessed using the Prediction model Risk Of Bias ASsessment Tool.ResultsOf 3,580 studies reviewed, 23 prediction models were identified. Age, tumor location, education level, baseline neurocognitive score, and radiation dose to the hippocampus were the most common predictors in the models. The Hopkins verbal learning and the trail making tests were the most frequent outcome assessment tools. All studies used regression as machine learning method. All models were judged to have a high risk of bias mainly due to issues in the analysis.ConclusionExisting models have limited quality and are at high risk of bias. Following recommendations are outlined in this review to improve future models: developing cognitive assessment instruments taking into account the peculiar traits of the different brain tumors and radiation modalities; adherence to model development and validation guidelines; careful choice of candidate predictors according to the literature and domain expert consensus; and considering radiation dose to brain substructures as they can provide important information on specific neurocognitive impairments. (shrink)

Lire les Dialogues de Platon avec en tete les questions soulevees par Nietzsche m'a fait saisir en eux une force et une etrangete usees par des myriades d'interpretations. Verifier combien Nietzsche platonise- m'a permis de percevoir une pensee qui, par-dela Oui et Non, accumule hypotheses et points d'interrogation. Ce livre tente d'expliciter une evidence jusque-la souterraine: la parente existant entre leurs manieres de philosopher. Qui reduit leurs philosophies a un ensemble de doctrines peut seulement voir ce qui les oppose: pensee (...) du devenir contre metaphysique de l'etre, interpretation contre recherche dialectique de la verite, corps pensant contre corps tombeau, la liste n'est pas close. Pour mettre en question ces oppositions, il fallait rappeler que penser est pour eux une aventure, une pluralite d'experiences joyeuses ou penibles ouvrant sur des chemins a explorer. La methode du contrepoint rigoureux, superposition de deux lignes melodiques qui n'exclut pas les dissonances, etait donc la plus indiquee. La mise en regard de leurs textes fait certes apparaitre des renversements, mais surtout des echos ou des chiasmes.Le Socrate musicien- qu'etait Platon et le Dionysos philosophos- dont Nietzsche se disait le disciple sont les figures croisees d'un philosophe que l'un invente et l'autre reinvente - d'un philosophe qui, ni metaphysicien ni anti-metaphysicien, est capable d'interroger impitoyablement comme de chanter au-dessus de la vie. Cette autre maniere de philosopher est, peut etre, ce dont la philosophie a aujourd'hui besoin. M. D. (shrink)

The three intertwining careers of William Torrey Harris [1835-1909] in philosophy, philosophy of education, and educational administration converge in twelve of the Annual Reports of the board of directors of the St. Louis public schools, most of the essential features of which he formulated as the superintendent of schools from 1867-79. These twelve reports, comprising philosophical and educational principles, have been acclaimed nationally and internationally to be among the most valuable official publications in American educational literature. The major purpose of (...) this paper is to clarify the nature and scope of the philosophical principles of Harris expressed in his Annual Reports. The areas of philosophy represented are metaphysics, anthropology, epistemology, ethics, and philosophy of religion. While the motivation and context of these philosophical principles are pedagogical in orientation, it is evident that Harris produced here a philosophical synthesis worthy of consideration in a formal survey of the history of American philosophy. (shrink)

Monique Roelofs’s The Cultural Promise of the Aesthetic is groundbreaking in its nuanced account of the potential and limitations of the aesthetic for creating a more just, humane world. Particularly timely are Roelofs’s analyses of the ways in which racial and gender stereotypes are reinforced and the operations of what she calls “racialized aesthetic nationalism,” the tendencies of aesthetic values to shore up schisms along racial, ethnic, and national lines. I raise questions, however, about the appropriateness of aesthetic criticism (...) that stresses sins of omission, the desirability of insisting that the broad nexus of social relations always be kept in view, and the danger that foregrounding minority group membership and gender will reduce individuals in marked categories to mere exemplifications of such status. (shrink)

Social interactions in daily life necessitate the integration of social signals from different sensory modalities. In the aging literature, it is well established that the recognition of emotion in facial expressions declines with advancing age, and this also occurs with vocal expressions. By contrast, crossmodal integration processing in healthy aging individuals is less documented. Here, we investigated the age-related effects on emotion recognition when faces and voices were presented alone or simultaneously, allowing for crossmodal integration. In this study, 31 young (...) adults (M = 25.8 years) and 31 older adults (M = 67.2 years) were instructed to identify several basic emotions (happiness, sadness, anger, fear, disgust) and a neutral expression, which were displayed as visual (facial expressions), auditory (nonverbal affective vocalizations) or crossmodal (simultaneous, congruent facial and vocal affective expressions) stimuli. The results showed that older adults performed slower and worse than younger adults at recognizing negative emotions from isolated faces and voices. In the crossmodal condition, although slower, older adults were as accurate as younger except for anger. Importantly, additional analyses using the ‘race model’ demonstrate that older adults benefited to the same extent as younger adults from the combination of facial and vocal emotional stimuli. These results help explain some conflicting results in the literature and may clarify emotional abilities related to daily life that are partially spared among older adults. (shrink)

For Beauvoir, literature provides unique access into the concrete life out of which philosophical reflection is born. Nowhere are the complications of ambiguous ethical choice more sensitively portrayed in her writings than in her fictional characters – particularly her women – as they navigate their way through webs of deceit, patriarchal control, manipulation, authenticity, desire, and passion in an attempt to ground their identities in a kind of absolute meaning. This chapter explores the theme of failed feminine identity‐formation in three (...) characters from Beauvoir's literary corpus: Françoise from She Came to Stay, Régine from All Men Are Mortal, and Monique from the short story, “The Woman Destroyed.” All three characters touch on themes surrounding the desire for and ultimate failure to obtain fixed meaning and an absolute identity. (shrink)

Introduction, W G Runciman Social Evolution in Primates: The Role of Ecological Factors and Male Behaviour, Carel P van Schaik Determinants of Group Size in Primates: A General Model, R I M Dunbar Function and Intention in the Calls of Non-Human Primates, Dorothy L Cheney & Robert M Seyfarth Why Culture is Common, but Cultural Evolution is Rare, Robert Boyd & Peter J Richerson An Evolutionary and Chronological Framework for Human Social Behaviour, Robert A Foley Friendship and the Banker?s Paradox: (...) Other Pathways to the Evolution of Adaptations for Altruism, John Tooby & Leda Cosmides The Early Prehistory of Human Social Behaviour: Issues of Archaeological Inference and Cognitive Evolution, Steven Mithen The Emergence of Biologically Modern Populations in Europe: A Social and Cognitive ?Revolution??, Paul Mellars Responses to Environmental Novelty: Changes in Men?s Marriage Strategies in a Rural Kenyan Community, Monique Borgerhoff Mulder Genetic Language Impairment: Unruly Grammars, M Gopnik, J Dalalakis, S E Fukuda, S Fukuda & E Kehayia The Emergence of Cultures among Wild Chimpanzees, Christophe Boesch Terrestriality, Bipedalism and the Origin of Language, Leslie C Aiello Conclusions, John Maynard Smith. (shrink)

Is the United States "the land of equal opportunity" or is the playing field tilted in favor of those whose parents are wealthy, well educated, and white? If family background is important in getting ahead, why? And if the processes that transmit economic status from parent to child are unfair, could public policy address the problem? Unequal Chances provides new answers to these questions by leading economists, sociologists, biologists, behavioral geneticists, and philosophers.New estimates show that intergenerational inequality in the United (...) States is far greater than was previously thought. Moreover, while the inheritance of wealth and the better schooling typically enjoyed by the children of the well-to-do contribute to this process, these two standard explanations fail to explain the extent of intergenerational status transmission. The genetic inheritance of IQ is even less important. Instead, parent-offspring similarities in personality and behavior may play an important role. Race contributes to the process, and the intergenerational mobility patterns of African Americans and European Americans differ substantially.Following the editors' introduction are chapters by Greg Duncan, Ariel Kalil, Susan E. Mayer, Robin Tepper, and Monique R. Payne; Bhashkar Mazumder; David J. Harding, Christopher Jencks, Leonard M. Lopoo, and Susan E. Mayer; Anders Björklund, Markus Jäntti, and Gary Solon; Tom Hertz; John C. Loehlin; Melissa Osborne Groves; Marcus W. Feldman, Shuzhuo Li, Nan Li, Shripad Tuljapurkar, and Xiaoyi Jin; and Adam Swift. (shrink)

Recent advances in wireless technologies have led to the development of intelligent, in-vehicle safety applications designed to share information about the actions of nearby vehicles, potential road hazards, and ultimately predict dangerous scenarios or imminent collisions. These vehicle safety communication (VSC) technologies rely on the creation of autonomous, self-organizing, wireless communication networks connecting vehicles with roadside infrastructure and with each other. As the technical standards and communication protocols for VSC technologies are still being developed, certain ethical implications of these new (...) information technologies emerge: Coupled with the predicted safety benefits of VSC applications is a potential rise in the ability to surveil a driver engaging in her everyday activities on the public roads. This paper will explore how the introduction of VSC technologies might disrupt the “contextual integrity” of personal information flows in the context of highway travel and threaten one’s “privacy in public.” Since VSC technologies and their related protocols and standards are still in the developmental stage, the paper will conclude by revealing how close attention to the ethical implications of the remaining design decisions can inform and guide designers of VSC technologies to create innovate safety applications that increase public safety, but without compromising the value of one’s privacy in public. (shrink)

Vedic Voices: Intimate Narratives of a Living Andhra Tradition. By David M. Knipe. New York: Oxford University Press, 2015. Pp. xxii + 340, illus. $35.

In lieu of an abstract, here is a brief excerpt of the content:Opining the articuli fidei:Thomas Aquinas on the Heretic’s Assent to the Articles of FaithM. V. DoughertyTHOMAS AQUINAS’S ACCOUNT of the infused virtue (habitus) of faith presupposes that some intrinsically intelligible truths are beyond the range of the natural cognitive abilities of human beings. The possession of the virtue of faith allows the believer to transcend certain natural epistemic limitations so that he can assent to truths that are necessary (...) for salvation. Consonant with the Catholic theological tradition, Aquinas refers to such truths as the articles of faith (articuli fidei), and stock examples include propositions concerning the Trinity and the Incarnation.1In light of the many and well-known texts from the Corpus Thomisticum that highlight the disproportion or incommensurability between the articles of faith and the natural cognitive abilities of human beings, it would not be unreasonable for one to assume that faith is required to assent to such articles of faith [End Page 1] in this life. Such an interpretive assumption could be expressed as:A1: A human being can assent to the articles of faith in this life if and only if the human being is fortified with the infused virtue of faith.One might be led to ascribe A1 to Aquinas when one considers that he criticizes the Pelagians precisely for maintaining that the assent to matters of faith is caused by nothing other than free will.2 Still further, one might think that strong evidence for A1 is Aquinas’s claim that “free will does not suffice for believing, since those things that are of faith are above reason.”3I argue, however, that A1’s identification of the virtue of faith as a necessary condition for the assent to the articles of faith does not adequately reflect Aquinas’s position, despite the many texts that may suggest such a view.4 That Aquinas does not endorse A1 can be made evident by examining his largely overlooked account of the epistemic state of the heretic (haereticus). To be sure, most commentators who explore the Thomistic treatment of heresy focus on the psychology of error underlying the heretic’s denial of one or more of the articles of faith.5 In the present paper I take an alternate path, however, focusing on those epistemic acts whereby the heretic gets its [End Page 2] right, so to speak, by correctly assenting to some of the articles of faith. Aquinas maintains that the heretic does not possess the infused virtue of faith yet still assents to all the articles of faith except for the one or more articles that he denies. Bereft of faith, the heretic “holds those things that are of faith by another mode than through faith.”6 This seemingly anomalous epistemic condition deserves consideration.7I. Intellects without FaithThe heretic appears to be cognitively privileged, since without faith he assents to the things that are of faith, seemingly overcoming without divine assistance the aforementioned disproportion between the limited range of reason and the articles of faith. Aquinas is aware of the apparent difficulty; in the Summa theologiae he defuses the rather unusual objection that heretics appear to have greater cognitive capacities than the faithful, since heretics routinely and unassistedly assent to those higher truths without possessing the virtue of faith.8 Aquinas concludes that the heretic holds the articles of faith by opinion (opinio), not faith.What makes one a heretic? Frequently Aquinas identifies obstinacy (pertinacia, instantia) as a necessary condition for heresy.9 The cause of heresy is at times identified with pride [End Page 3] (superbia).10 On Aquinas’s account, heresy is a species of unbelief (infidelitas) and every heretic is a schismatic.11 But the heretic does get many things right. If one were to deny all of the articles of faith, one would not qualify as a heretic, but would simply be a nonbeliever or an apostate. So, apart from the denial of an article (or a few articles) that specifies heretics as the distinct kind of heretic they happen to be, heretics for the most part succeed in assenting to most—but not all—of the articles of faith.Although the... (shrink)

Книга представляет собой систематический научный труд. Это принципиально новая наука! Здесь нет механики! Исследование мироздания - "качественное", и законы, есть законы.

Selected articles on Marxism, nationalism, and humanism by a radical humanist leader and Communist international; includes study on his life and work.

Emphasizing the human body in all of its forms, Beauty Unlimited expands the boundaries of what is meant by beauty both geographically and aesthetically. Peg Zeglin Brand and an international group of contributors interrogate the body and the meaning of physical beauty in this multidisciplinary volume. This striking and provocative book explores the history of bodily beautification; the physicality of socially or culturally determined choices of beautification; the interplay of gender, race, class, age, sexuality, and ethnicity within and on the (...) body; and the aesthetic meaning of the concept of beauty in an increasingly globalized world. Foreward by Carolyn Korsmeyer. Authors include Noel Carroll, Gregory Velazco Y Trianosky, Monique Roelofs, Whitney Davis, Eleanor Heartney, Diana Tietjens Meyers, Phoebe M. Farris, Mary Devereaux, Jo Ellen Jacobs, Karina L. Cespedes-Cortes and Paul C. Taylor, Fedwa Malti-Douglas, Stephen Davies, Jane Duran, Valerie Sullivan Fuchs, Keith Lehrer, Allen Douglas, Cynthia Freeland, Eva Kit Wah Man, Mary Bittner Wiseman, and Peg Brand's essay, "ORLAN Revisited: Disembodied Virtual Hybrid Beauty.". (shrink)

Learning a mapping involves finding regularities in a training set and generalization to novel patterns. Clark & Thornton's type distinction has been discussed in terms of generalization, but has limited value in this respect. However, in terms of detection of regularities in the training set, the distinction is more valid, as it provides a measure of complexity and correlates with the size of search space.

System of References To keep footnotes to a minimum, references to classical sources are incorporated into the body of the narrative, normally in the ...

In this issue we are publishing articles criticizing the " gang of four" selected from recent sources in the People's Republic of China. The major recent sources in the People's Republic of China. The major theoretical criticism centers around the idea and theory of "bourgeois rights" attributed to the "gang of four.".